abstract：:Patients with HIV and AIDS are living longer because of advancements in antiretroviral therapy. These patients are often susceptible to debilitating inflammatory disorders that are refractory to standard treatment. We discuss the relationship of tumor necrosis factor-alpha and HIV and then review 27 published cases of...

journal_title：Journal of the American Academy of Dermatology

authors： Gallitano SM,McDermott L,Brar K,Lowenstein E

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Inability of topical medications to penetrate via nail plate brings a great challenge to clinicians in treating onychomycosis. Furthermore, oral medications are not appropriate for all patients because of drug interactions, adverse effects, and contraindications. OBJECTIVE:We sought to evaluate the clinical...

journal_title：Journal of the American Academy of Dermatology

authors： Bhatta AK,Keyal U,Huang X,Zhao JJ

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Comparing effectiveness of biologics in real-world settings will help inform treatment decisions. OBJECTIVES:We sought to compare therapeutic responses among patients initiating infliximab, adalimumab, or etanercept versus ustekinumab during the Psoriasis Longitudinal Assessment and Registry (PSOLAR). METH...

journal_title：Journal of the American Academy of Dermatology

authors： Strober BE,Bissonnette R,Fiorentino D,Kimball AB,Naldi L,Shear NH,Goyal K,Fakharzadeh S,Calabro S,Langholff W,You Y,Galindo C,Lee S,Lebwohl MG

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Bullous pemphigoid is an autoimmune blistering skin disease that predominantly affects the elderly. Conventional therapy using high-dose systemic corticosteroids and immunosuppressive agents can be ineffective in some patients and produce adverse events and relapses. Hence, alternate therapies are required. ...

journal_title：Journal of the American Academy of Dermatology

authors： Ahmed AR,Shetty S,Kaveri S,Spigelman ZS

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:In recent years, increasing emphasis has been placed on value-based health care delivery. Dermatology must develop performance measures to judge the quality of services provided. The implementation of a national complication registry is one such method of tracking surgical outcomes and monitoring the safety ...

journal_title：Journal of the American Academy of Dermatology

authors： Council ML,Alam M,Gloster HM Jr,Bordeaux JS,Carroll BT,Leitenberger JJ,Wisco OJ,Maher IA

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The adult burden of atopic dermatitis (AD) is poorly characterized. OBJECTIVE:We sought to characterize AD burden in adults with moderate to severe disease from the patient's perspective. METHODS:Patient-reported outcomes collected at screening in a phase 2b clinical trial of dupilumab included pruritus nu...

journal_title：Journal of the American Academy of Dermatology

authors： Simpson EL,Bieber T,Eckert L,Wu R,Ardeleanu M,Graham NM,Pirozzi G,Mastey V

更新日期：2016-03-01 00:00:00

abstract：:Malignant melanoma is considered the most lethal skin cancer if it is not detected and treated during its early stages. About 10% of melanoma patients report a family history of melanoma; however, individuals with features of true hereditary melanoma (ie, unilateral lineage, multigenerational, multiple primary lesions...

journal_title：Journal of the American Academy of Dermatology

authors： Soura E,Eliades PJ,Shannon K,Stratigos AJ,Tsao H

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Current knowledge of angiolymphoid hyperplasia with eosinophilia (ALHE) derives from retrospective reports and case series, leading to a nonevidence-based treatment approach. OBJECTIVE:We sought to systematically review the literature relating to cutaneous ALHE to estimate its epidemiology and treatment out...

journal_title：Journal of the American Academy of Dermatology

authors： Adler BL,Krausz AE,Minuti A,Silverberg JI,Lev-Tov H

更新日期：2016-03-01 00:00:00

abstract：:Pruritus is a common and often times difficult to treat symptom in many dermatologic and systemic diseases. For pruritus with an inflammatory or autoimmune origin, therapies such as topical corticosteroids and antihistamines are often initiated. However, in the case that these and additional systemic therapies are ine...

journal_title：Journal of the American Academy of Dermatology

authors： Sharma D,Kwatra SG

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Despite a lack of evidence that dysplastic nevi are precursors to melanoma, a large proportion of dermatologists continue to treat them as such. Emerging data suggest that histologic grading approach may result in many unnecessary excisions. OBJECTIVE:Using a nongrading approach to diagnosis of Clark/dyspla...

journal_title：Journal of the American Academy of Dermatology

authors： Lozeau DF,Farber MJ,Lee JB

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Cutaneous polyarteritis nodosa (cPAN) is a skin medium vessel neutrophilic arteritis with livedo, nodules, and ulcerations. Macular lymphocytic arteritis (MLA) is a small arteritis with erythematous or pigmented macules and typical histologic features (a lymphocytic infiltrate, concentric fibrin ring, no dis...

journal_title：Journal of the American Academy of Dermatology

authors： Buffiere-Morgado A,Battistella M,Vignon-Pennamen MD,de Masson A,Rybojad M,Petit A,Cordoliani F,Begon E,Flageul B,Mahr A,Bagot M,Bouaziz JD

更新日期：2015-12-01 00:00:00

abstract：:Current classifications for hidradenitis suppurativa (HS), such as the Hurley staging system, are not very specific. The absence of rigorous classifications is incongruous with the clinical variability of the condition. There is no pathognomonic sign for HS that leads to a diagnosis that is unquestionable. Consequentl...

journal_title：Journal of the American Academy of Dermatology

authors： van der Zee HH,Jemec GB

更新日期：2015-11-01 00:00:00

abstract：:Pyoderma gangrenosum, severe acne, and suppurative hidradenitis (PASH) syndrome can prove refractory to treatment and is characterized by relapses and recurrences. The combination of antibiotic therapy and surgery can produce success in the management of the syndrome. Acute treatment is required, but maintenance thera...

journal_title：Journal of the American Academy of Dermatology

authors： Join-Lambert O,Duchatelet S,Delage M,Miskinyte S,Coignard H,Lemarchand N,Alemy-Carreau M,Lortholary O,Nassif X,Hovnanian A,Nassif A

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Psoriasis and migraine are common conditions with potential overlap of pathophysiological mechanisms. Both these diseases have been associated with increased cardiovascular risk but little is known about their interplay. OBJECTIVE:We sought to investigate the link between psoriasis, and the risk of new-onse...

journal_title：Journal of the American Academy of Dermatology

authors： Egeberg A,Mallbris L,Hilmar Gislason G,Skov L,Riis Hansen P

更新日期：2015-11-01 00:00:00

abstract：LEARNING OBJECTIVES:At the conclusion of this learning activity, physician participants should be able to assess their own diagnostic and patient management skills and use the results of this exercise to help determine personal learning needs. Instructions: In answering each question, refer to the specific directions p...

journal_title：Journal of the American Academy of Dermatology

authors： Hung CT,Wang WM

更新日期：2015-11-01 00:00:00

abstract：:Acute generalized exanthematous pustulosis is a severe cutaneous adverse reaction characterized by the rapid development of nonfollicular, sterile pustules on an erythematous base. It is attributed to drugs in the majority of cases. Antibiotics are the most common cause of acute generalized exanthematous pustulosis; h...

journal_title：Journal of the American Academy of Dermatology

authors： Szatkowski J,Schwartz RA

更新日期：2015-11-01 00:00:00

abstract：:Pain is a central component of illness and suffering, yet unfortunately it is frequently undertreated. In dermatology, many acute and chronic conditions are characterized by pain that may require therapeutic intervention in addition to medical treatment aimed at treating the primary disease. To date, however, there ar...

journal_title：Journal of the American Academy of Dermatology

authors： Enamandram M,Rathmell JP,Kimball AB

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Patients with cutaneous melanoma metastases have experienced excellent responses to intralesional interleukin (IL)-2. This has led to its recent inclusion into the US National Comprehensive Cancer Network guidelines for management of cutaneous melanoma metastases. Despite this, intralesional IL-2 has not bee...

journal_title：Journal of the American Academy of Dermatology

authors： Shi VY,Tran K,Patel F,Leventhal J,Konia T,Fung MA,Wilken R,Garcia MS,Fitzmaurice SD,Joo J,Monjazeb AM,Burrall BA,King B,Martinez S,Christensen SD,Maverakis E

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:A number of factors other than those identified by the American Joint Committee on Cancer (AJCC) may have prognostic significance in the evaluation of melanoma. OBJECTIVE:We sought to evaluate commonly recorded clinical features potentially associated with aggressive melanoma. METHODS:We conducted a retros...

journal_title：Journal of the American Academy of Dermatology

authors： Donahue T,Lee CY,Sanghvi A,Obregon R,Sidiropoulos M,Cooper C,Merkel EA,Yélamos O,Ferris L,Gerami P

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:ESPRIT is an ongoing, 10-year, observational registry, evaluating long-term safety and effectiveness of adalimumab treatment in routine clinical practice for patients with moderate to severe, chronic plaque psoriasis. OBJECTIVES:Initial 5-year results are reported. METHODS:Two populations were analyzed: th...

journal_title：Journal of the American Academy of Dermatology

authors： Menter A,Thaçi D,Papp KA,Wu JJ,Bereswill M,Teixeira HD,Rubant S,Williams DA

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Safety profiles of systemic biologic agents for the treatment of psoriasis and psoriatic arthritis (PsA) encompass a wide spectrum of adverse events. To date, no uniform evidence-based guidelines exist regarding screening and monitoring patients who are undergoing biologic therapy. OBJECTIVE:We sought to id...

journal_title：Journal of the American Academy of Dermatology

authors： Ahn CS,Dothard EH,Garner ML,Feldman SR,Huang WW

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Rosacea is a chronic inflammatory skin disease. Inflammation plays a prominent role in atherosclerosis and its complications. OBJECTIVE:We sought to investigate the associations of rosacea with cardiovascular disease risk factors and cardiovascular diseases from a nationwide population-based database. METH...

journal_title：Journal of the American Academy of Dermatology

authors： Hua TC,Chung PI,Chen YJ,Wu LC,Chen YD,Hwang CY,Chu SY,Chen CC,Lee DD,Chang YT,Liu HN

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The reported efficacy of imiquimod for lentigo maligna varies widely, without consensus on tumor or treatment factors that can impact tumor clearance. OBJECTIVE:We sought to provide a more precise estimate of clearance rates in patients with lentigo maligna who are treated with imiquimod and to analyze fact...

journal_title：Journal of the American Academy of Dermatology

authors： Mora AN,Karia PS,Nguyen BM

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Confetti-like depigmentation was noted in patients reporting recent worsening of vitiligo. OBJECTIVE:We sought to determine if confetti-like depigmentation is a marker of rapidly progressing vitiligo. METHODS:Review of patient records and images of patients from a vitiligo registry resulted in 7 patients w...

journal_title：Journal of the American Academy of Dermatology

authors： Sosa JJ,Currimbhoy SD,Ukoha U,Sirignano S,O'Leary R,Vandergriff T,Hynan LS,Pandya AG

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Risk of cutaneous melanoma is increased among organ transplant recipients (OTRs) but outcome has rarely been evaluated. OBJECTIVE:We sought to assess melanoma characteristics and prognosis among OTRs versus the general population. METHODS:Using Swedish health care registers, we identified melanomas in OTRs...

journal_title：Journal of the American Academy of Dermatology

authors： Krynitz B,Rozell BL,Lyth J,Smedby KE,Lindelöf B

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Segmental vitiligo (SV) is characterized by a unilateral and localized distribution, early onset, and stable disease after rapid progression. And SV is often associated with poor response to various treatment modalities. OBJECTIVE:We sought to evaluate the effectiveness of combination therapy with 308-nm ex...

journal_title：Journal of the American Academy of Dermatology

authors： Bae JM,Yoo HJ,Kim H,Lee JH,Kim GM

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The identification of "normal" dermoscopic patterns of acquired melanocytic nevi provides better diagnostic accuracy for melanoma in people with black skin. OBJECTIVE:We sought to describe melanocytic lesions (numbers and anatomic distributions) in skin types V and VI compared with skin types I and II, acco...

journal_title：Journal of the American Academy of Dermatology

authors： Tuma B,Yamada S,Atallah ÁN,Araujo FM,Hirata SH

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:There is controversy regarding a potential increased risk of lymphoma in patients with atopic dermatitis (AD). OBJECTIVE:To assess the risk of lymphoma and the role of topical treatments in patients with AD. METHODS:A systematic literature search and a separate meta-analysis were performed on case control ...

journal_title：Journal of the American Academy of Dermatology

authors： Legendre L,Barnetche T,Mazereeuw-Hautier J,Meyer N,Murrell D,Paul C

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:BRAF mutations occur in some melanomas. We hypothesized that BRAF mutation rates may differ in melanomas found in Asian compared to white populations. OBJECTIVE:We performed a metaanalysis of BRAF mutations and their associations with the clinicopathologic characteristics of primary melanoma (PM), with a su...

journal_title：Journal of the American Academy of Dermatology

authors： Kim SY,Kim SN,Hahn HJ,Lee YW,Choe YB,Ahn KJ

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Sézary syndrome is a cutaneous T-cell lymphoma characterized by erythroderma and leukemic involvement. OBJECTIVE:We sought to define the clinical, biologic, and histopathologic features of Sézary syndrome without erythroderma. METHODS:Features of patients with Sézary syndrome and normal-appearing skin or s...

journal_title：Journal of the American Academy of Dermatology

authors： Henn A,Michel L,Fite C,Deschamps L,Ortonne N,Ingen-Housz-Oro S,Marinho E,Beylot-Barry M,Bagot M,Laroche L,Crickx B,Maubec E

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Psoriasis's effect on diabetes onset is well documented, but its effect on course of diabetes is poorly understood. OBJECTIVE:We sought to compare risks of developing microvascular and macrovascular complications between diabetic patients with and without psoriasis. METHODS:Adults with 2 or more diabetes d...

journal_title：Journal of the American Academy of Dermatology

authors： Armstrong AW,Guérin A,Sundaram M,Wu EQ,Faust ES,Ionescu-Ittu R,Mulani P

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Ultraviolet B phototherapy is underused because of costs and inconvenience. Home phototherapy may alleviate these issues, but training is spotty, and many physicians are not comfortable prescribing home phototherapy. OBJECTIVE:The purpose of this review is to provide a practical guide for recognizing approp...

journal_title：Journal of the American Academy of Dermatology

authors： Anderson KL,Feldman SR

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Many targeted therapies used in the treatment of cancer can lead to the development of xerosis, but the incidence and relative risk of xerosis have not been ascertained. OBJECTIVE:We conducted a systematic review and metaanalysis of clinical trials, to ascertain the incidence and risk of developing xerosis ...

journal_title：Journal of the American Academy of Dermatology

authors： Valentine J,Belum VR,Duran J,Ciccolini K,Schindler K,Wu S,Lacouture ME

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Kaposi varicelliform eruption (KVE), or herpes simplex virus (HSV) superinfection of pre-existing skin lesions, may complicate Darier disease. OBJECTIVE:We sought to compare the clinical features and outcomes of patients with Darier disease who developed KVE superinfection with those who did not. METHODS:A...

journal_title：Journal of the American Academy of Dermatology

authors： Vogt KA,Lohse CM,El-Azhary RA,Gibson LE,Lehman JS

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Inherited susceptibility genes have been associated with histopathologic characteristics of tumors. OBJECTIVE:We sought to identify associations between histology of melanomas and CDKN2A genotype. METHODS:This was a case-control study design comparing 28 histopathologic tumor features among individuals wit...

journal_title：Journal of the American Academy of Dermatology

authors： Sargen MR,Kanetsky PA,Newton-Bishop J,Hayward NK,Mann GJ,Gruis NA,Tucker MA,Goldstein AM,Bianchi-Scarra G,Puig S,Elder DE

更新日期：2015-03-01 00:00:00

abstract：:Sound surgical technique is necessary to achieve excellent surgical outcomes. Despite the fact that dermatologists perform more office-based cutaneous surgery than any other specialty, few dermatologists have opportunities for practical instruction to improve surgical technique after residency and fellowship. This 2-p...

journal_title：Journal of the American Academy of Dermatology

authors： Miller CJ,Antunes MB,Sobanko JF

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Antibodies against transcriptional intermediary factor (TIF)-1γ are associated with malignancy in dermatomyositis (DM). Identification of clinical findings associated with anti-TIF-1γ antibodies in DM is a high priority for both patient diagnosis and risk assessment. OBJECTIVE:We sought to define the clinic...

journal_title：Journal of the American Academy of Dermatology

authors： Fiorentino DF,Kuo K,Chung L,Zaba L,Li S,Casciola-Rosen L

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Voriconazole, an antifungal agent, is associated with various cutaneous reactions, including phototoxicity, accelerated photoaging, and skin cancer. Incidence and risk factors for these reactions in children have not been well described. OBJECTIVE:We sought to determine the incidence of and factors associat...

journal_title：Journal of the American Academy of Dermatology

authors： Sheu J,Hawryluk EB,Guo D,London WB,Huang JT

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Mycoplasma pneumoniae infection is associated with extrapulmonary complications, including mucocutaneous eruptions. These eruptions, which have been termed either "Stevens-Johnson syndrome" or "erythema multiforme" in the literature, may differ from drug-induced Stevens-Johnson syndrome or viral-associated e...

journal_title：Journal of the American Academy of Dermatology

authors： Canavan TN,Mathes EF,Frieden I,Shinkai K

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Azathioprine is efficacious in the treatment of severe childhood atopic dermatitis; however, robust data on adverse effects in this population are lacking. OBJECTIVE:We sought to assess adverse effects of azathioprine treatment in a pediatric atopic dermatitis cohort, and make recommendations for monitoring...

journal_title：Journal of the American Academy of Dermatology

authors： Fuggle NR,Bragoli W,Mahto A,Glover M,Martinez AE,Kinsler VA

更新日期：2015-01-01 00:00:00